Andreessen Horowitz had a seed investment of $250,000 in Instagram, but when Facebook acquired them for $1 billion, he made a very, very nice amount of money that weekend. Horowitz was one of Instagram's earliest investors, and general partner Ben Horowitz took to a blog to post the following:

Ordinarily, when someone criticizes me for only making 312 times my money, I let the logic of their statement speak for itself. However, in this case, the narrative that some critics put forth has the nasty side effect of casting two outstanding entrepreneurs-Kevin and Dalton Caldwell-in an unfair light and glosses over an important ethical issue that we faced.

The company didn't follow-up on its investment, as they had a conflict of interest with another company it funded, Picplz. Picplz being another photo-sharing concept that didn't have the same oomph as Instagram. Then last week The New York Times ran a story saying that Andreessen Horowitz had basically screwed up its investment in the company. The decision to fund Picplz "was a calculated bet against Instagram and it left Mr. Systrom livid" reported The Times.

So what? The company made an investment, it turned into $78 million. I'm just jealous.