if you're often attaching and removing hard drives from your system manually, you'd be wise to look at getting yourself a removable hard drive tray. Thermaltake have just introduced a new one dubbed the Max4, designed for 3.5" SATA drives and taking up one of your vacant 5.25" drive bays.
Rack technology is another product added to the MAX4 line. The Max4 HDD rack is easily installed in any 5.25" drive bay and supports all of today's mainstream SATA hard disks with a transmission speed of up to 3Gbp/s. Patented designed connectors reduce poor attachments from the HDD to the SATA interface increasing the life of the interface disconnect/removal up to 50,000 times. The smart ejection mechanism provides gentle and smooth insertion and ejection of hard drives.